AKI is a sudden loss of kidney function. It is typically caused by other health conditions or events that reduce blood flow or oxygen to the kidneys. It can also be caused by food, medications or other substances that are toxic to the kidneys, or that cause a prolonged blockage of urine flow.
Causes of AKI include:
- Infection.
- Blood or fluid loss
- Medications (such as non-steroidal anti-inflammatory drugs (NSAIDs)) which are used to reduce swelling or relieve pain from headaches, colds, flu, and other ailments. These include ibuprofen [Advil, Motrin], ketoprofen, and naproxen [Aleve].
- Heart attack, heart failure, and other conditions leading to decreased heart function
- Severe allergic reactions
- Major surgery
- Blockage of urine flow (ex: prostate disease, kidney stones, and tumours)
- Kidney diseases (ex: glomerulonephritis)
AKI Symptoms
Patients with AKI often don’t experience any symptoms unless it is severe. Signs and symptoms of AKI will differ depending on the causes and may include:
- Little or no urine output
- Swelling in legs, ankles, or feet
- Fatigue or tiredness
- Shortness of breath
- Confusion
- Loss of appetite, nausea, or vomiting
- Seizures or coma in severe cases
Diagnosing AKI
AKI is often diagnosed during a hospital stay for another issue or condition. It can be identified through blood tests, urine tests, and sometimes imaging (such as ultrasound or CT).
AKI may also be diagnosed in the outpatient setting based on blood and urine tests. These tests will usually be requested when there is a reason to suspect AKI such as an illness or severe dehydration.
If you're not hospitalized but experiencing symptoms of AKI, your doctor will inquire about your symptoms and medications before conducting urine and blood tests to diagnose the issue.